When Fructose Flips the Survival Switch: What Happens at High Exposure and When to Act
Fructose isn’t merely “empty calories.” At sufficient exposure — from added sugars or from glucose converted inside the body —…
Biocatalysis vs brute-force chemistry: how Merck made enlicitide decanoate producible as the first oral PCSK9 candidate
Merck published a Science paper describing a new, scalable biocatalytic synthesis for enlicitide decanoate — an investigational oral PCSK9 inhibitor.…
Naked mole rat HAS2 in mice: a proof-of-concept that raises clear checkpoints for human translation
Researchers at the University of Rochester inserted a naked mole rat version of the HAS2 gene into mice, raising tissue…
Restoring a mouse’s youthful gut microbes reversed liver aging and blocked tumors by suppressing MDM2
New experiments at the University of Texas Medical Branch show that returning each mouse’s own preserved youthful gut bacteria to…
Lubiprostone’s kidney signal: increased bacterial spermidine protects mitochondria and slows eGFR loss
Lubiprostone — a common prescription for chronic constipation — slowed decline in kidney function in moderate chronic kidney disease (CKD)…
When BLV appears in breast tissue — interpreting the Texas 59% finding and realistic next steps
Multiple international studies now show bovine leukemia virus (BLV) DNA is detected more often in breast cancer tissue than in…
When low testosterone may speed glioblastoma: NIH-funded findings on stress hormones, immunity, and what to watch
NIH-funded work led by Cleveland Clinic investigators, including Dr. Justin Lathia, links testosterone loss to faster glioblastoma (GBM) growth through…
NEOPRISM‑CRC: Nine weeks of pembrolizumab before surgery left 32 UK MMR‑deficient/MSI‑high bowel cancer patients relapse‑free after nearly three years
A UK trial called NEOPRISM‑CRC gave 32 people with stage 2 or 3 MMR‑deficient/MSI‑high bowel cancer a nine‑week course of…
FDA Fast Track for tazbentetol follows positive Phase 2a signals — next stop: phase 3
The FDA has granted Fast Track designation to tazbentetol, an oral drug from Spinogenix that uses a synaptic-regenerative mechanism to…
UC San Diego’s IV cardiac‑ECM nanoparticles bind injured vessels and reduce inflammation — the trial checkpoints to watch
An intravenously injectable biomaterial made from decellularized cardiac extracellular matrix (ECM) can circulate as nanoscale particles, home to damaged blood…