Should You Follow NutritionFacts.org’s Daily Dozen? Practical start points, progression, and check signals
NutritionFacts.org is a nonprofit, ad-free platform that translates peer-reviewed nutrition research into practical tools centered on whole plant foods. This…
Recent rat studies mapped an lPBN astrocyte “fullness” switch via glutamate — next checkpoints for translation
New experiments in rats show that activating astrocytes in the lateral parabrachial nucleus (lPBN) sharply reduces food intake through glutamate…
Oral semaglutide vs orforglipron: what ORION’s indirect comparison tells clinicians and patients now
The ORION analysis from Novo Nordisk used population-adjusted indirect comparison methods to contrast oral semaglutide 25 mg tablets with Eli…
OTOF gene therapy restored hearing after one inner‑ear injection in a 10‑patient trial — who it helps and what comes next
A single inner‑ear injection of AAV‑mediated gene therapy that replaces the defective OTOF gene restored measurable hearing in all ten…
CK1 inhibitors protect human cone photoreceptors in a 2,700‑compound organoid screen — safety and delivery are the next hurdles
A large-scale screen using 20,000 human retinal organoids with GFP-labeled cones found that inhibiting casein kinase 1 (CK1) consistently protected…
DFNZ: NIH’s nitazene‑derived opioid produced two‑hour pain relief in rodents without respiratory depression
NIH scientists report a novel opioid, DFNZ, that in rodents produced sustained pain relief for over two hours while, unusually…
Whole-genome sequencing finds a reproducible microbial fingerprint unique to colorectal cancer
Whole‑genome sequencing (WGS) of more than 9,000 cancer patients has revealed that colorectal tumors—alone among common tumor types—consistently host a…