DFNZ: NIH’s nitazene‑derived opioid produced two‑hour pain relief in rodents without respiratory depression
NIH scientists report a novel opioid, DFNZ, that in rodents produced sustained pain relief for over two hours while, unusually…
Whole-genome sequencing finds a reproducible microbial fingerprint unique to colorectal cancer
Whole‑genome sequencing (WGS) of more than 9,000 cancer patients has revealed that colorectal tumors—alone among common tumor types—consistently host a…
Solriamfetol delivers measurable wakefulness gains for early‑morning shift workers with shift work disorder
Clinical trial data show solriamfetol can modestly but reliably increase wakefulness in people with shift work disorder who start work…
Efzimfotase alfa: clear pediatric bone‑health benefit; adult gains concentrated in pediatric‑onset HPP
Efzimfotase alfa, a next‑generation enzyme replacement therapy from AstraZeneca Rare Disease, produced a clear, statistically significant bone‑health signal in treatment‑naïve…
Salt substitutes cut blood pressure — who should try them, who should not, and how to decide
Salt substitutes — typically sodium chloride partially replaced by potassium chloride — are an inexpensive, evidence-backed way to lower blood…