Blocking Ant2 reprograms T cells — not starves them — and strengthens tumor control in mice
Blocking the mitochondrial ADP/ATP carrier Ant2 does not simply “turn off” T cells. In preclinical work led by Prof. Michael…
Recent rat studies mapped an lPBN astrocyte “fullness” switch via glutamate — next checkpoints for translation
New experiments in rats show that activating astrocytes in the lateral parabrachial nucleus (lPBN) sharply reduces food intake through glutamate…
OTOF gene therapy restored hearing after one inner‑ear injection in a 10‑patient trial — who it helps and what comes next
A single inner‑ear injection of AAV‑mediated gene therapy that replaces the defective OTOF gene restored measurable hearing in all ten…
CK1 inhibitors protect human cone photoreceptors in a 2,700‑compound organoid screen — safety and delivery are the next hurdles
A large-scale screen using 20,000 human retinal organoids with GFP-labeled cones found that inhibiting casein kinase 1 (CK1) consistently protected…
Whole-genome sequencing finds a reproducible microbial fingerprint unique to colorectal cancer
Whole‑genome sequencing (WGS) of more than 9,000 cancer patients has revealed that colorectal tumors—alone among common tumor types—consistently host a…
When ocean plastic goes microscopic: 27 million tons of North Atlantic nanoplastics and why cleanup won’t work
The headline finding is stark: researchers now estimate about 27 million tons of nanoplastics — particles smaller than one micrometer…
Erythritol’s trade-off: fewer calories versus lab‑shown brain‑vessel and clotting risks
New lab research from the University of Colorado Boulder shows erythritol—common in sugar‑free and keto products—can impair brain blood‑vessel cells…