Oral semaglutide vs orforglipron: what ORION’s indirect comparison tells clinicians and patients now
The ORION analysis from Novo Nordisk used population-adjusted indirect comparison methods to contrast oral semaglutide 25 mg tablets with Eli…
DFNZ: NIH’s nitazene‑derived opioid produced two‑hour pain relief in rodents without respiratory depression
NIH scientists report a novel opioid, DFNZ, that in rodents produced sustained pain relief for over two hours while, unusually…
Solriamfetol delivers measurable wakefulness gains for early‑morning shift workers with shift work disorder
Clinical trial data show solriamfetol can modestly but reliably increase wakefulness in people with shift work disorder who start work…
Efzimfotase alfa: clear pediatric bone‑health benefit; adult gains concentrated in pediatric‑onset HPP
Efzimfotase alfa, a next‑generation enzyme replacement therapy from AstraZeneca Rare Disease, produced a clear, statistically significant bone‑health signal in treatment‑naïve…
Fabhalta vs placebo: 49.3% slower eGFR decline and 43% fewer kidney‑failure events in IgA nephropathy — a progression‑slowing therapy, not a cure
Novartis’ Phase III APPLAUSE‑IgAN trial published in the New England Journal of Medicine and presented at the 2026 World Congress…
Retatrutide Phase 3 (TRANSCEND‑T2D‑1) cut A1C up to 2.0% and body weight up to 16.8% after 40 weeks
Eli Lilly’s investigational triple agonist retatrutide produced large reductions in both A1C and body weight in TRANSCEND‑T2D‑1, a 537‑person Phase…
Semaglutide linked to significantly lower psychiatric risks in large Sweden and Australia studies
Two recent registry analyses from Sweden and Australia — together following nearly 100,000 adults, including more than 20,000 people who…
Lecanemab: Fc-Driven Microglial Plaque Clearance vs. Modest Clinical Gain and ARIA Risk
Lecanemab’s main action depends on its Fc fragment calling microglia into action: recent work from VIB and KU Leuven shows…
Weekly injectable extended‑release buprenorphine increased prenatal opioid abstinence and reduced serious maternal adverse events
An NIH‑supported randomized trial of 140 pregnant adults with opioid use disorder found that weekly injectable extended‑release buprenorphine produced higher…
Melatonin for Kids: Useful in Specific Cases, Risky as a Routine Fix
Melatonin can help some children—especially those with neurodevelopmental disorders or clear circadian shifts—but product variability, rising accidental exposures, and sparse…