Efzimfotase alfa: clear pediatric bone‑health benefit; adult gains concentrated in pediatric‑onset HPP
Efzimfotase alfa, a next‑generation enzyme replacement therapy from AstraZeneca Rare Disease, produced a clear, statistically significant bone‑health signal in treatment‑naïve…
Salt substitutes cut blood pressure — who should try them, who should not, and how to decide
Salt substitutes — typically sodium chloride partially replaced by potassium chloride — are an inexpensive, evidence-backed way to lower blood…
Start with a brace, pool sessions, or progressive exercise for knee osteoarthritis — evidence from a 139‑trial meta‑analysis
Recent large-scale evidence finds that simple non-drug approaches — knee braces, hydrotherapy, and structured exercise — are the most consistently…
15–20 Minutes a Week of Vigorous Activity Linked to Large Drops in Dementia and Diabetes Risk
New evidence from wrist accelerometer data in more than 96,000 UK Biobank participants shows that very short weekly amounts of…
Fabhalta vs placebo: 49.3% slower eGFR decline and 43% fewer kidney‑failure events in IgA nephropathy — a progression‑slowing therapy, not a cure
Novartis’ Phase III APPLAUSE‑IgAN trial published in the New England Journal of Medicine and presented at the 2026 World Congress…
When ocean plastic goes microscopic: 27 million tons of North Atlantic nanoplastics and why cleanup won’t work
The headline finding is stark: researchers now estimate about 27 million tons of nanoplastics — particles smaller than one micrometer…
Erythritol’s trade-off: fewer calories versus lab‑shown brain‑vessel and clotting risks
New lab research from the University of Colorado Boulder shows erythritol—common in sugar‑free and keto products—can impair brain blood‑vessel cells…
Protein injections vs metabolites: how some gut bacteria directly rewire immune signals in Crohn’s
New studies show many common gut bacteria have type III secretion systems (T3SS) — microscopic syringe-like structures that can inject…
When to Lose Weight—and When to Protect Muscle: Practical thresholds and checkpoints for sarcopenic obesity in older adults
Sarcopenic obesity combines excess fat and low muscle mass and, in older adults, raises mortality and disability risk more than…
Had chronic gut inflammation? Remission isn’t a reset — lasting epigenetic and immune changes raise colorectal cancer risk
New experimental work from teams at the Broad Institute and Harvard, together with complementary findings from Weill Cornell Medicine, shows…